Sanitizer Raw Material

By Admin 08 May 2020

Sanitizer is a composition of chemicals which helps to kill to get rid of harmful microorganisms. At present, alcohol-based sanitizer, hand rubs, disinfectant are the only known means for rapidly and effectively deactivating a wide range of potentially harmful microorganisms and should be used to fight against COVID 19 (Coronavirus).

Sanitizers are generally of two types:

  1. Alcohol free
  2. Alcohol based

WHO recommends alcohol-based sanitizer, hand rubs, disinfectant should be used instead of alcohol free sanitizer to fight against COVID 19 based on the following factors:

 

  1. Alcohol based sanitizer has advantages of fast acting and broad-spectrum of microbicide activity with a minimal risk of generating resistance to antimicrobial agents;
  2.  
  3. Suitability for use in resource-limited or remote areas with lack of accessibility to sinks or other facilities for hand hygiene can use hand sanitizer, hand rubs or hand disinfectant;
  4. It has capacity to promote improved hand hygiene by making the process faster and more convenient;
  5. It also provides economic benefit by reducing annual costs for hand hygiene and also the raw material required is cheap and easily available.
  6.  

RAW MATERIAL TO BE USED:

There are two formulations for preparation of Alcohol based sanitizer. According to these formulations, following raw material is required for preparation of sanitizer:

 

  1. ETHANOL BASED
  2.  
  1. Ethanol
  2. Hydrogen peroxide
  3. Glycerol
  4. Sterile distilled or boiled cold water

 

  1. ALCOHOL BASED
  2.  
  1. Isopropyl alcohol
  2. Hydrogen peroxide
  3. Glycerol
  4. Sterile distilled or boiled cold water

 

  1. Glycerol: It is used as humectant which makes it a substance that helps to absorb or retain moisture but other emollients may be used for skin care, provided that glycerol is cheap, easily and widely available. It can be easily mixed in water and alcohol to form a homogeneous mixture and it also do not add to toxicity, or promote allergy.
  2. Hydrogen peroxide (H2O2): It is used to deactivate contaminating bacterial spores in the solution and is not an active substance for hand antiseptics.
  3. Any further substance added to both formulations should be clearly labelled on the container and be non-toxic in case of accidental ingestion.
  4. A colorant can be added to allow differentiation from other fluids, but that colorant substance should not add to toxicity, promote allergy, or interfere with antimicrobial properties. The addition of perfumes or dyes is not recommended due to risk of allergic reactions to the user of the sanitizer.
  5. Sterile distilled or boiled cold water: While sterile distilled water is preferred for making the formulations, boiled and cooled tap water can also be used as long as it is free of visible particles.

 

QUALITY OF RAW MATERIAL USED SHOULD ALSO BE CHECKED BEFORE MIXING THEM TO PREPARE SANITIZER:

 

For instance: If concentrated alcohol is obtained from local production, first verify the alcohol concentration and make the necessary adjustments in quantity to obtain the final recommended concentration. A device named alcoholmeter can be used to check and control the alcohol concentration of the final solution to be used;

 

Also, H2O2 and alcohol concentration can be measured by titrimetric reaction. A higher level of quality control of sanitizer can be performed using gas chromatography. Moreover, microbial contamination (including spores) in the solution can be checked by filtration.

 

 

PROCESS FOR PREPARATION OF SANITIZER

 

  • The alcohol/Ethanol for the formula to be used is poured into the large bottle or tank up to the prescribed mark.

 

  • Hydrogen peroxide is added using the measuring cylinder into the tank/large bottle.

 

  • Glycerol is also added using a measuring cylinder/measuring jug. As glycerol is very thick and sticks to the wall of the measuring cylinder, it should be rinsed with some sterile distilled or cold boiled water and then emptied into the bottle/tank.

 

  • The bottle/tank is then topped up to the required mark with sterile distilled or cold boiled water.

 

  • The lid or the screw cap is placed on the tank/bottle as soon as possible after adding all the substances, in order to prevent evaporation

 

  • The solution is mixed by gently shaking or by using a paddle where ever appropriate.

 

  • Immediately divide up the solution into its final containers and place the bottles in isolation for at least 72 hours before use. This allows time for any spores present in the alcohol or the new/re-used bottles to be destroyed and become safe to use again.

 

In these times of need and scarcity we Precult ITES Private Limited are here 24*7 to help and serve our people. We help to provide all types of raw material, machinery, equipment or services required for manufacture of sanitizer therefore there can be more and more production to serve.